I'm really liking the part about the Great Elders and the Archons. Maybe instead of Isis and Osiris Elders, maybe they are the only surviving Great Elders. And then if they are Great Elders and what is said in the quote is true, then they could have kids without the change effecting them.
Or, maybe they somehow perfected the technique that Abraham used to slow the change in himself, to basically remove the change altogether, and did the same thing for Sophie and Josh when they were first born, to make sure the Change wouldn't have an effect on them.
XD But, I don't know, and haven't read the books in a while(currently rereading the first) so I could be really far off.